21c Museum Hotel Louisville

700 W Main St | Louisville, KY 40202-2634  [SEE MAP]Louisville, KY  [SEE ADDRESS]

Courtesy of 21c Museum Hotel Louisville

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Unique art concept in a convenient location
Some recent guests said rates are expensive for the market

You'll be tempted to take home one of those red plastic penguins found in the lobby of this West Main Street hotel. Resist the urge, though: 21c does offer up poster art that you can pack in your suitcase upon checkout. Plus, there are plenty of other avant-garde 21st-century art pieces to peruse in the lobby, meeting spaces and rooms. But aesthetics aren't the only things recent guests appreciate about this boutique hotel. They also highlight the exemplary hospitality staff (led by swift room service) and the first-rate Proof on Main restaurant. Visitors should order the signature bison burger, washed down with one of Louisville's finest bourbons to get a taste of Kentucky's flavor.

Louisville, KY
Hotel Class
Property Type
Boutique hotel, 91 rooms
Primary View
City center, River
Modern, Historic
Best For
Business travelers, Couples, Groups, Solo travelers


  • 4.5Hotel Class
  • GOODCritic Rating


U.S. News analyzed more than 30,000 hotels to find the best in the USA, Europe, Canada, Mexico, Bermuda and the Caribbean, based on reputation among travel experts, guest reviews and hotel class ratings.

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Critic Reviews

Other Awards

  • Condé Nast Readers' Choice List 2018

Condé Nast Traveler


Created from abandoned tobacco and bourbon warehouses, 21c Museum Hotel in Louisville doubles as a contemporary art museum with more than 9,000 square feet of exhibition space.



When it opened in 2006, 21C immediately attracted national acclaim for its elegant restoration of a 19th-century building, attention to service, and cutting-edge art collection.



Walking into this hotel is much like entering a gallery of contemporary art. Expect rotating selections of statues, paintings and art installations, many of which reflect a peculiar sensibility.

AAA/CAA Four Diamond Awards 2019

Other Awards

  • Condé Nast Readers' Choice List 2018

Guest Reviews

A hotel's guest rating is calculated using data provided under license by TripAdvisor. A total of 1619 have reviewed the 21c Museum Hotel Louisville, giving it a rating of 4.5, on a scale of 1-5.

TripAdvisor Travel Rating: 

TripAdvisor Travel Rating: TripAdvisor Traveler Rating 4.5 based on 1619 reviews 4.5 (based on 1619 reviews)

Guest Rooms

Set within a group of 19th-century warehouses, the 21c Museum Hotel Louisville's modern guest rooms were designed by Deborah Berke and offer large windows, high ceilings and original artwork, with some rooms featuring exposed brick walls. All guest rooms include luxurious bedding, 42-inch flat-screen TVs and original artwork.
  • Nespresso coffee machines
  • Bathrooms have MALIN+GOETZ products and plush robes

Standard room size320 square feet

  • Internet (free)
  • Premium channels
  • Workspace/desk
  • Minifridge
  • Bathrobes/slippers
  • Minibar
  • Shower/tub combo
  • Separate shower
  • Separate tub
  • Wireless Internet
  • Guest rooms with patios and balconies
  • Adjoining rooms available

Location & Parking

Situated in downtown Louisville, the 21c Museum Hotel Louisville combines contemporary art with boutique-style accommodations. The modern property offers rotating art exhibits and the Louisville Slugger Museum & Factory is less than a block away. There is an award-winning Southern bistro, Proof on Main, as well as a spa and meeting space. Given its design style, the property is best suited for adults.
  • Within walking distance of Evan Williams Bourbon Experience, KFC Yum! Center and the Riverwalk
  • 4 miles north of Churchill Downs and the Kentucky Derby Museum
  • 8 miles north of Louisville International Airport
  • 24-hour valet parking ($32)
  • 24-hour self-parking
  • Airport shuttle
  • Car service (with fee)

Within walking distance of:

  • Grocery store
  • Movie theater
  • Theater
  • Shopping
  • Bus stop
  • Train station
  • Subway/metro stop
  • Restaurants
  • Beach


21c Museum Hotel Louisville's Proof on Main offers a contemporary Southern bistro-style experience. The restaurant serves an array of dishes crafted from locally sourced ingredients, along with more than 120 of Kentucky’s best bourbons.
  • Rotating art exhibits within restaurant
  • Seasonal menus
  • In-room dining available from 6 a.m. to midnight on Sundays through Thursdays, and until 1 a.m. on Fridays and Saturdays

Number of restaurants1

Cuisine TypesAmerican

  • Fine dining
  • Casual dining
  • Quick service cafe/coffee shop/marketplace
  • Bar/lounge
  • Room service
  • 24-hour room service
  • Free breakfast


The 21c Museum Hotel Louisville has an on-site spa available for guest use. The facility offers massage services, as well as a sauna and steam room.
  • In-room massage services available upon request
  • Advance reservations required for spa services

Services offered:

  • Massage
  • Facial
  • Body treatments (i.e. scrubs, wraps)
  • Salon services
  • Outdoor treatment area
  • Steam room
  • Sauna


While the 21c Museum Hotel Louisville has an art focus and is designed to appeal to adults, the hotel does offer cribs for no additional charge and rollaways for $30 per night, as well as some child-friendly, in-room dining options. The hotel also offers a Kid's Exploration Package, which includes two tickets to the Kentucky Science Center and a tent for in-room camping.
    • Kids club
    • Cribs
    • High chairs


    There is a 24-hour on-site fitness center at the 21c Museum Hotel Louisville. The facility offers cardio machines and strength-training equipment.
    • Complimentary bike rental available on first-come, first-serve basis
    • Weight equipment
    • Cardio equipment
    • Yoga mats
    • Free fitness classes
    • Premium fitness classes (with fee)
    • Bicycles (free)
    • Tennis
    • Guided runs
    • Paddle boats
    • Motor boats


    The 21c Museum Hotel Louisville has more than 9,000 square feet of art-filled event space for business meetings and gatherings. There is one conference room, four private meeting rooms and a large atrium that can host up to 450 people.
    • Catering provided by Proof on Main
    • On-site event team
    • Room blocks available

    Number of meeting rooms6

    • Business center
    • Meeting rooms
    • Meeting and event planners available


    The 21c Museum Hotel Louisville is a dog-friendly property. Advance notice is required, and guests must sign a pet waiver at check-in.
    • $75 nonrefundable pet cleaning fee
    • 50-pound weight limit
    • Pets allowed (with fee)
    • Dog walking
    • Pet-sitting


    The 21c Museum Hotel Louisville offers a modern art-filled setting for weddings. The property can host receptions for up to 250 guests, as well as rehearsal dinners, post-wedding brunches and bridal showers.
    • Customizable gourmet catering from Proof on Main
    • 21c art car limousine available
    • Pre-wedding massage services
    • Custom welcome gifts for guests can be arranged

    Maximum wedding guest capacity250

    • Hotel hosts weddings
    • Outdoor space for weddings
    • Wedding planners available

    Editor’s note: Hotel information is updated periodically. If this is your property and you notice any inaccuracies, please let us know. If you are interested in obtaining a badge to display on your website or in other media, please contact us.

    Find the Best Price

    at the 21c Museum Hotel Louisville

    Press the down arrow key to interact with the calendar and select a date. Press the question mark key to get the keyboard shortcuts for changing dates.

    Press the down arrow key to interact with the calendar and select a date. Press the question mark key to get the keyboard shortcuts for changing dates.