Cheeca Lodge & Spa

At 27 acres, this may be the largest resort in the Keys, and it's also big on included amenities. In the main lodge, West Indies–style rooms boast luxurious touches like elegant soaking tubs that fill in a stream from the ceiling.

The 214-room Cheeca Lodge & Spa is a luxury resort set on extensive, lush grounds in Islamorada, offering plenty of on-site features, including a nine-hole golf course, a pretty beach with a long fishing pier, a full-service spa, six tennis courts, and two pools (one for adults only). Three restaurants serve tasty seafood, sushi, and Italian fare, but they're pricey, and there's a fun tiki bar on the beach.

Extensively overhauled in 2009 following a fire, this sprawling, historic resort on 27 lush acres of beachfront offers world-class amenities in a laid-back setting. The standard rooms have West Indies–style decor and marble bathrooms, and 840-square-foot 'premier suites' feature floor-to-ceiling windows opening to ocean or island views, as well as open-air tubs for two on roomy balconies.

Located just 90 minutes from Miami International Airport, this expansive property offers a little bit of everything the Keys has to offer. In addition to its 214 well-appointed rooms and suites, decked out in a tropical-chic style, the family-friendly resort is home to 27 acres of lush gardens, a Jack Nicklaus-designed 9-hole golf course, a top-of-the-line spa, a saltwater lagoon for swimming and snorkeling, and 1,100 feet of private beachfront.

Surrounded by 27 acres of tropical gardens, the lodge faces 1,200-feet of beach and even has a saltwater lagoon for swimming and snorkeling. This being the Sportfishing Capital of the World, there's plenty a serious angler can do here – from casting a line from the longest pier in the Keys to chartering a boat (guests have unlimited use of fishing gear and sea kayaks).