At the top of Santa Lucía Hill, you'll be rewarded with picturesque views and lovely fountains.
As the sun goes down, Santiago's bright city lights provide a stark contrast between the skyscrapers and the Andes mountains.
Portillo's pristine slopes lures powder hounds to the Andes each winter.
Chile is known for its wine, and Santiago makes a great home base for those looking to tour the vineyards in the nearby Maipo and Casablanca valleys.
Towering over the Plaza de Armas, the Metropolitan Cathedral is a hard-to-miss attraction.
Wander through artsy Bellavista and you'll discover modern shops and restaurants rubbing shoulders with colorful homes and centuries-old mansions.
At the top of this scenic (and steep) hill, you'll find a statue of the Lady of the Immaculate Conception (Virgen de la Inmaculada Concepción), not to mention impressive views of the city and the snow-covered Andes.
Fashion-savvy visitors flock to this privately owned museum, which features a varied assortment of haute-couture and collectors' items like an original 1958 Ford Thunderbird.
Miguel Vera León
Established in 1541 by Spanish conquistador and city founder Pedro de Valdivia, the Plaza de Armas features a mish-mash of modern sites and historical landmarks.
Honoring victims lost during General Augusto Pinochet's rule — which lasted from 1973 to 1990 — this museum displays photographs, letters and artifacts from the 17 years Pinochet was in power.
Courtesy Museo de la Memoria y los Derechos Humanos
This whimsical former residence of Noble prize-winning poet Pablo Neruda is a must-see Santiago attraction.
In the vibrant Plaza de Armas, comedians and dancers entertain visitors every day of the year.
Though the climb is quite a trek, once you reach the top of Santa Lucía Hill, you'll discover scenic views of the city below and plenty of spots to relax after a day of exploration.
At this market, you'll discover a bounty of freshly caught seafood and a colorful selection of fruit, vegetables and spices.
Anchored in the Andes — just 102 miles northeast of Santiago — Portillo's enticing trails and soft powder have been luring ski enthusiasts since it opened its doors in the 1930s.
In Santiago, arresting views of the Andes' jagged peaks and the city's shiny buildings vie for your attention.
Colorful street art adds a pop of color to Santiago's urban sprawl.
FXEGS Javier Espuny
Meandering through Patio Bellavista's chic shops in the trendy Bellavista neighborhood makes for a relaxing afternoon stroll.
If you're looking to hit the slopes in June, July and August, head to Portillo, the oldest ski area in South America. Here, you'll find well-groomed trails and spectacular scenery comprising snow-capped mountains and the emerald Inca Lake.
Occupying a 20th century neoclassical palace, this museum lures guests with its impressive architecture and versatile collection. The galleries include works from Chilean and foreign artists, and interlace modern pieces with artwork from colonial times.