In 1516, Jews in Venice were forced to move to a small northwestern section of the island. Considered to be the world's first ghetto, residents were only allowed to leave the neighborhood during the day and were then locked up at night and guarded. Today, this area is a part of the Cannaregio sestiere (district) and is filled with restaurants and shops (some offering kosher products), a Jewish museum as well as several synagogues, which are open for touring. Although it's free to wander around the neighborhood – and you might want to do just that – the synagogue tours do cost. 

For a deeper understanding of the ghetto's history, recent travelers recommend booking a walking tour through an outfitter like Viator. Several water bus lines stop near the neighborhood, but you can also reach it on foot – it's about a 10-minute walk from the Lista di Spagna. For more information, visit the neighborhood's website.